Florida Southern is among the elite NCAA Division II athletic programs in the country, boasting an astounding 30 NCAA National Championships, more than 60 NCAA Regional Championships, 24 NCAA Individual National Champions, and six NCAA Relay Champions (men's swimming). The Moccasins have also dominated the Sunshine State Conference, winning more than 200 combined SSC regular-season and tournament titles.

FSC has won the SSC Mayor's Cup, an annual award that goes to the top athletic program in the conference (men's or women's), a total of 24 times (13 men's/11 women's). In addition, the Mocs have been in the top 15 of the NACDA Director's Cup, which ranks the top athletic programs in the nation, a total of nine times.

Florida Southern has made more than 300 NCAA Postseason appearances in 16 different sports, and brought home a national title in six different sports. The Mocs have more NCAA National Championships in men's golf (13) and baseball (nine) than any other school at the Division II level.

30 NCAA National Championships (Team)
Men's Golf (13) - 1981, 1982, 1985, 1986, 1990, 1991, 1995,
1996, 1998, 1999, 2000, 2010, 2017
Baseball (9) - 1971, 1972, 1975, 1978, 1981, 1985, 1988, 1995, 2005
Women's Golf (4) - 2000, 2001, 2002, 2007
Men's Basketball (2) - 1981, 2015
Softball (1) - 1993
Women's Lacrosse (1) - 2016 

24 NCAA Individual National Championships
Men's Golf (9) - Tom Gleeton (1979), Tom Patri (1981), Lee Janzen (1985),
Matt Saglio (1999), Jeff Klauk (2000), Steve Sokol (2001), Tim Crouch (2013 & 2014), John VanDerLaan (2018)
Women's Golf (6) - Shanna Nagy (1996 & 1998),
Lisa Cave (1999 & 2000), Jana Peterkova (2001 & 2002)
Men's Swimming (4) - Jeb Halfacre (2010, 2011 & 2012 – 200-yd. backstroke), Matthew Holmes (2018 - 400 IM) 
Women's Swimming (5) - Mary O'Sullivan (2011 – 200-yd backstroke & 200-yd. freestyle)
Alli Crenshaw (2013 – 1,000-yd. & 1,650-yd freestyle; 2014 – 1,000-yd. freestyle)

6 NCAA Relay National Championships
Men's Swimming (6)
200-yd. Medley Relay - 2013, 2016
400-yd. medley relay - 2011, 2012, 2016
800-yd. freestyle relay - 2012

22 NCAA National Runner-Up Finishes
Men's Golf (5) - 1979, 1980, 1984, 1988, 2001
Women's Golf (5) - 1998, 1999, 2003, 2004, 2012
Baseball (4) - 1979, 1982, 1984, 1994
Men's Swimming (2) - 2013, 2014
Softball (2) - 1987, 2004
Women's Lacrosse (2) - 2017, 2018
Men's Basketball (1) - 1982
Volleyball (1) - 2017

61 NCAA Regional Championships
Baseball (21) - Men's Basketball (10) - Softball (8)
Volleyball (5) - Men's Tennis (4) - Men's Golf (4)
Women's Golf (3) - Men's Cross Country (3)
Women's Basketball (2) - Women's Lacrosse (1) - Women's Tennis (1) 

320 NCAA Post-Season Appearances
Men's Golf (46) - Baseball (44) - Men's Basketball (30)
Volleyball (31) - Women's Cross Country (27) - Men's Cross Country (24)
Men's Tennis (21) - Softball (20) - Women's Golf (20)
Women's Tennis (18) - Women's Basketball (13), Women's Swimming (9)
Men's Swimming (9), Women's Soccer (3), Women's Lacrosse (4), Men's Soccer (1)

147 Sunshine State Conference Regular Season Titles
Softball (27) - Men's Basketball (22) - Baseball (17) - Men's Golf (16)
Men's Cross Country (17) - Women's Basketball (13) - Women's Tennis (10) 
 Women's Cross Country (7) - Volleyball (8) - Women's Golf (4)
Women's Lacrosse (4) - Men's Tennis (2)

53 Sunshine State Conference Postseason Tournament Titles
Men's Basketball (23) - Women's Basketball (11) - Men's Swimming (4)
Softball (3) - Volleyball (4) - Women's Tennis (3) - Women's Lacrosse (3) 
Baseball (1) - Women's Swimming (1)